Hey, We are Gametimeprime and this guide is about Karthus Build s13 in League of Legends.
Best Karthus build guides for League of Legends s13. We works hard to help you craft the best Karthus build for the meta. Learn more about Karthus’s Runes, Items, Matchups.
Karthus Jungle
Karthus Spells
Karma Runes
- Domination
- Precision
Karthus Items
Starters
Full Items
Karthus Skill
PASSIVE – DEATH DEFIED
Upon dying, Karthus enters a spirit form that allows him to continue casting spells.
Q- LAY WASTE
Karthus unleashes a delayed blast at a location, dealing damage to nearby enemies. Deals increased damage to isolated enemies.
W- WALL OF PAIN
Karthus creates a passable screen of leeching energy. Any enemy units that walk through the screen have their Movement Speed and Magic Resist reduced for a period.
E- DEFILE
Karthus passively steals energy from his victims, gaining Mana on each kill. Alternatively, Karthus can surround himself in the souls of his prey, dealing damage to nearby enemies, but quickly draining his own Mana.
R- REQUIEM
After channeling for 3 seconds, Karthus deals damage to all enemy champions.
Karthus Ability Order
Skill order: Q> E > W

Karthus Combo
Karthus combo in a Team Figth is: Use flash into the TF and active the (E)Defile. You will do a lot of Damage. And then use Zhonya and SPAM the (Q)Lay Waste. ONLY WHEN YOU ARE DEATH USE (R)Requiem!
Karthus Tips and Tricks
Karthus Pros and Cons
Pros:
- High damage.
- Great in team fights.
- Versatile builds and play styles.
- Low skill floor and high ceiling.
- Great carry potential.
Cons:
- Needs to hit a lot of skill shots.
- No mobility.
Karthus Threats & Synergies
Threats
Synergies